利培酮所致粒细胞减少文献概述
Chinese Journal of Drug Abuse Prevention and Treatment(2016)
Abstract
利培酮是苯丙异嗯唑类抗精神病药物,是目前治疗精神分裂症的一线药物.近年来国内有文献报道,本品可致粒细胞减少,现概述如下:
颜少广报道,患女,36岁,因偏执性精神病给予奋乃静治疗,后给予利培酮治疗,最大用量6mg/d,同时逐渐替换奋乃静治疗,用药前白细胞5.8×109/L,用药1个月后复查血常规示白细胞3.0×109/L,粒细胞为2.4×109/L,3天后白细胞降至2.2×109/L,粒细胞0.8×109/L,逐停药,予对症治疗,半个月后白细胞计数升至6.0×109/L,粒细胞升至2.5×109/L[1].
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