结肠定位释药双氯芬酸钠包衣片体内外相关性
JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY(2002)
Abstract
目的研制时间依赖型口服结肠定位释药双氯芬酸钠包衣片.方法用释放度测定法研究双氯芬酸钠包衣片体外释放行为,用HPLC法测定包衣片在家犬体内的血药浓度,并计算出相关参数,进行体内外相关性考察.结果体外平均延迟释放时间为4~5 h时,体内平均时滞为3~6 h,达到预期结果.结论本文研制的双氯芬酸钠片有进一步开发的价值.
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