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结肠定位释药双氯芬酸钠包衣片体内外相关性

邹梅娟,程刚,崔福德,刘国良,郝秀华,李蔚雯

JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY（2002）

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Abstract
目的研制时间依赖型口服结肠定位释药双氯芬酸钠包衣片.方法用释放度测定法研究双氯芬酸钠包衣片体外释放行为,用HPLC法测定包衣片在家犬体内的血药浓度,并计算出相关参数,进行体内外相关性考察.结果体外平均延迟释放时间为4～5 h时,体内平均时滞为3～6 h,达到预期结果.结论本文研制的双氯芬酸钠片有进一步开发的价值.
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