甲状腺乳头状癌中 HER-2、CyclinD1的表达与颈部淋巴结转移的相关性
Journal of Hunan Normal University (Medical Science)(2015)
Abstract
目的:探索甲状腺乳头状癌中 HER-2、CyclinD1蛋白表达与颈部淋巴结转移的相关性。方法:选取同期住院手术病理诊断为甲状旁腺乳头状癌及瘤旁正常患者组织蜡块标本各85例,标本均经常规病理诊断确诊。采用免疫组化染色,Envision 两步法检测 HER-2和 CyclinD1蛋白表达,对比两组蛋白表达情况,进行统计学分析。结果:实验组中 HER-2和 CyclinD1蛋白表达阳性率均显著高于对照组;两蛋白表达不存在显著相关性;淋巴结转移组 CyclinD1蛋白阳性率(96.43%)高于非转移组(74.47%)。结论:HER-2蛋白与甲状腺乳头状癌密切相关, CyclinD1蛋白不仅与甲状腺乳头状癌有关,还与淋巴结转移有关。
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Key words
Papillary thyroid carcinoma,HER-2,Cyclind1,Lymph node metastasis
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