上消化道出血患者中幽门螺杆菌毒株分型分析

CHINESE JOURNAL OF MEDICINE（2004）

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Abstract

目的探讨上消化道出血患者的Ⅰ型幽门螺杆菌感染状况.方法对341例上消化道出血患者行胃镜检查,ELISA法测定患者血清幽门螺杆菌(Hp)CagA和VacA抗体进行毒株分型.结果上消化道出血患者的Ⅰ型幽门螺杆菌检出率70.09%(239/341).胃溃疡71.43%(40/56),十二指肠溃疡80.22%(146/182),胃癌78.57%(11/14)与急性胃粘膜病变Ⅰ型幽门螺杆菌检出率44.90%(22/49)相比差异有显著性(P＜0.001,P＜0.001,P＜0.05).结论上消化道出血患者的Ⅰ型幽门螺杆菌感染率高,胃、十二指肠溃疡、胃癌Ⅰ型幽门螺杆菌感染显著高于急性胃粘膜病变.

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