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缺碘性甲状腺肿动物模型的建立及评价

Wei CHONG, Wei CHEN,Wei-ping TENG,Zhong-yan SHAN,Ying JIN,Xiao-ping ZHANG,Lian-min XI,Nuo ZHANG,Na MAN,Ya-jie TONG,Yang YU,Cheng-ling FAN,Hai-xia GUAN,Yu-shu LI

JOURNAL OF CHINA MEDICAL UNIVERSITY（2005）

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Abstract
目的:建立可靠的缺碘性甲状腺肿动物模型.方法:给予4周龄Wistar大鼠低碘饲料和去离子水喂养3个月,全面观察甲状腺各项相关指标的变化.结果:尿碘中位数、甲状腺组织碘和激素含量及血清总甲状腺素水平显著降低,甲状腺相对重量、吸碘率、蛋白水解酶活性和血清甲状腺刺激激素水平显著增加.甲状腺在光镜下呈增生性甲状腺肿的表现.结论:成功建立了缺碘性甲状腺肿动物模型.
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