筋骨草水煎液对急性肺炎的保护作用研究
Journal of North Sichuan Medical College(2017)
Abstract
目的:研究筋骨草水煎液对小鼠急性肺炎的保护作用及机制.方法:用LPS吸入法建立急性肺炎模型,设空白对照组、模型组、筋骨草水煎液组和地塞米松组.观察小鼠肺组织病理,测定肺指数、肺湿/干比,采用酶联免疫吸附试验法检测肺泡灌洗液中肿瘤坏死因子-α、白细胞介素-1β的含量.结果:筋骨草组与模型组比较减轻了急性肺炎小鼠肺组织病变,数据由SPSS 13.0软件分析,小鼠肺指数、肺湿干比明显降低,差异显著(P<0.05),降低肺泡灌洗液中TNF-α、IL-1β的含量,差异显著(P<0.05).结论:筋骨草水煎液有一定的抗炎作用,可以缓解小鼠急性肺炎症状,其机制可能与降低TNF-α、IL-1β的含量有关.
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Key words
Ajuga decumbens,Acute lung inflammation,Protective effect
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