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氢氧镁铝抗实验性胃溃疡的研究

林军,陈家欢,唐平,杨斌,陈美芳

GUANGXI MEDICAL UNIVERSITY（2000）

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Abstract
目的:探讨新型抗酸剂氢氧镁铝对实验性胃溃疡的影响.方法:利用小鼠应激性胃溃疡、小鼠烧灼性胃溃疡、大鼠利血平性胃溃疡及大鼠幽门结扎性胃溃疡的模型,同时在幽门结扎性胃溃疡模型中观察其对胃液量、胃酸酸度、胃液pH值及胃蛋白酶活性的影响.结果:氢氧镁铝可明显抑制应激性胃溃疡、幽门结扎性胃溃疡和利血平性胃溃疡的形成,且可促进烧灼性胃溃疡的愈合,对胃酸酸度和胃蛋白酶活性有明显的抑制作用.结论:氢氧镁铝可通过抑制胃酸酸度和胃蛋白酶活性起到抗胃溃疡作用.
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