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活血通腑方对术后腹腔粘连大鼠Nrf2、HO-1及NQO1表达的影响

Li-li YANG,Li ZENG,Wen-lin LI,Zi-yu LIAN,Hai-ting GAO, Kang-li XUE

Journal of Nanjing University of Traditional Chinese Medicine（2017）

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Abstract
目的 探讨活血通腑方对术后腹腔粘连大鼠粘连部位Nrf2、HO-1及NQO1蛋白及mRNA的影响.方法 通过腹腔粘连评分评价腹腔粘连水平,Western blot法检测Nrf2核蛋白、HO-1和NQO1蛋白表达,qPCR检测Nrf2、HO-1和NQO1 mRNA表达.结果 活血通腑方能够显著降低肉眼腹腔粘连评分(P<0.01).活血通腑方组Nrf2核蛋白、HO-1和NQO1蛋白表达以及mRNA表达显著升高(P<0.01).结论 活血通腑方对术后腹腔粘连大鼠粘连部位Nrf2、HO-1及NQO1表达有显著影响,可能通过调节Nrf2及下游因子的表达进而提升抗氧化应激能力,发挥抗腹腔粘连效应.
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Key words
postoperative peritoneal adhesion,oxidative stress,Nrf2-ARE signaling pathway
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