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吸烟者外周血单个核细胞差异表达miRNA与mRNA调控网络

Xiao-min DANG,Xiao-yan QU,Dong SHANG,Lan YANG,Wei-jia WANG,Ying LI,Fei-yan LI,Ying CHANG

Journal of Xi'an Jiaotong University(Medical Sciences)（2018）

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Abstract
目的 探讨吸烟者外周血单个核细胞(PBMC)差异表达的miRNA与mRNA调控网络及相关信号通路.方法 收集20名健康非吸烟者与17名健康吸烟者的外周静脉血,分离PBMC后提取总RNA,分别进行miRNA和mRNA表达谱芯片检测.在差异表达的miRNA和mRNA范围内通过数据库预测miRNA对mRNA的调控关系,并进行信号通路富集分析.结果 与健康非吸烟者相比,吸烟者PBMC有miRNA与mRNA的差异表达,其差异表达基因的GO富集分析表明,血小板来源生长因子信号通路、胆囊收缩素受体信号通路、T细胞活化和表皮生长因子受体信号通路是主要的信号通路.结论 吸烟者PBMC中差异表达的miRNA与mRNA调控网络可能与某些疾病的潜在危险因素相关.
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