陈旧心肌梗死患者胱抑素C水平及预后相关性研究
Journal of Kunming Medical University(2015)
Abstract
目的探讨陈旧心肌梗死(old myocardial infarction,OMI)患者血清胱抑素C(cystatinC,CysC)水平的变化及其与心功能的关系,分析因心血管事件发生再人院患者治疗前后心功能变化及血清CysC水平的相关性,同时明确血清CysC水平变化与肾小球滤过率(GFR)是否有相关性.方法测定81例陈旧心肌梗死患者血清CysC浓度等指标,以患者24 h内首次血清CysC值作为基线,≥1.50 mg/L为CysC显著增高组,<1.50 mg/L为CysC正常或轻微增高组.心功能按纽约心脏协会(NYHA)分级,NYHAⅠ级46例,NYHAⅡ级14例,NYHAⅢ级10例,NYHAⅣ级11例,对照组为体检健康者30例.结果OMI患者血清CysC水平与对照组比较均增加,差异有统计学意义(P<0.05).血清CysC与心功能严重程度呈正相关.血清CysC显著增高组的患者心血管事件和再住院率都明显增加.治疗后血清CysC水平与治疗前比较均下降,差异有统计学意义(P<0.05).血清CysC与GFR呈负相关.结论OMI患者血清CysC水平明显升高,随着血清CysC升高,心衰程度加重,心血管事件及再住院率增加.血清CysC的水平反映心衰患者早期肾脏功能的受损.
MoreKey words
Old myocardial infarction,CystatinC,Glomerular filtration rate,Prognosis
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined