CK19、Galectin-3、E-cad和VEGF在甲状腺微小乳头状癌中的表达及临床意义
Journal of Ningxia Medical University(2016)
Abstract
目的 探讨甲状腺微小乳头状癌中CK19、Galectin-3、E-cad和VEGF的表达及临床意义.方法 采用免疫组化法检测42例甲状腺微小乳头状癌及30例甲状腺乳头状增生中CK19、Galectin-3、E-cad和VEGF的表达情况.结果 CK19、Galectin-3和VEGF在甲状腺微小乳头状癌中的表达阳性率(95.2%、90.5%和92.8%)均高于在甲状腺乳头状增生的表达阳性率(20%、6.7%和13.3%)(P=0.000);甲状腺微小乳头状癌中E-cad的表达阳性率(23.8%)低于甲状腺乳头状增生(93.3%)(P=0.000).结论 CK19、Galectin-3、和VEGF在甲状腺微小乳头状癌灶呈高表达,E-cad在甲状腺微小乳头状癌中呈低表达,其联合检测可提高甲状腺微小乳头状癌诊断的准确性.
MoreKey words
papillary thyroid microcarcinoma,CK19,Galectin-3,E-cad,VEGF,immunohistochemical staining
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