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去整合蛋白及其抗肿瘤作用研究进展

孙德军,谷红东,杨春伟,赵轶卓,常淑芳,颜伟群,侯立中

JOURNAL OF JILIN UNIVERSITY(MEDICINE EDITION)（2003）

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Abstract
去整合蛋白是一类分子量较小,由49～84个氨基酸组成,富含半胱氨酸的生物活性因子.去整合蛋白二硫桥形成的环中含有精氨酸-甘氨酸-天冬氨酸(RGD)结构,能够竞争性地与整合素结合,从而抑制整合素参与的生理活动.去整合蛋白能够抗血小板聚集和肿瘤细胞转移,具有广阔应用前景.
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