丙型肝炎病毒与肝细胞癌关系研究进展
ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY(2003)
Abstract
据估计,目前全世界感染丙型肝炎病毒(HCV)者约1.7亿.我国大陆以HCV 1b、2a型为多,其中肝细胞癌(HCC)和(或)癌周肝组织HCV抗原阳性率达36.2% (25/69) ~72.7% (48/66),这种差异与检测方法的不同有关.HCV感染后通常经由慢性肝炎→肝硬化路径引起HCC.HCV抗原表达与肝细胞恶性转化和肿瘤相关基因的功能改变有关,是HCC发生的重要危险因子之一.
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