CA125与慢性心力*衰竭关系的探讨
wf(2016)
Abstract
目的:探讨CA125与慢性心力衰竭的关系,同时探讨其与BNP、LVEF有无关联性。方法选取在我院心内科住院的120例慢性心力衰竭患者作为病例组,并依据NYHA分级标准,进一步将病例组分为 I-II级组、III级组及IV级组;同期选取100例健康体检者作为对照组,采用酶联免疫吸附法( ELISA)分别测定各组血清CA125、BNP水平,采用B超测定各组LVEF数值。结果:(1)心力衰竭组CA125数值为130.15±63.12U/ml显著高于对照组25.67±6.46U/ml(P﹤0.05);心力衰竭组BNP数值为458.12±200.46 ng/L显著高于对照组63.41±40.66 ng/L(P﹤0.05);心力衰竭组LVEF为45.65±7.33%显著低于对照组64.23±5.35%(P﹤0.05)。(2)NYHA I-II组BNP、CA125均显著低于NYHA III组及 IV组( P﹤0.05);NYHA III组 BNP、CA125显著低于 NYHA IV组( P﹤0.05);NYHA I-II组LVEF高于NYHA III组,两组间比较差异无统计学意义( P﹥0.05);NYHA I-II组LVEF显著高于NYHA IV组(P﹤0.05);NYHA III组LVEF显著高于NYHA IV组(P﹤0.05)。(3)CA125与BNP存在正相关性( P﹤0.05),与LVEF存在负相关性(P﹤0.05)。结论(1)CA125可能参与了慢性心力衰竭的发生、发展,对于慢性心力衰竭诊断、治疗可能有一定的价值。(2)CA125与BNP、LVEF可能存在相关性。
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