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乙肝免疫球蛋白阻断乙肝病毒母婴传播的临床观察

何明娇,徐玉苑,李耘,奚丽鸾,黄少贤,陈利红,蓝兰英, 刘青妮

JOURNAL OF JINAN UNIVERSITY（NATURAL SCIENCE & MEDICINE EDITION）（2005）

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Abstract
目的:探讨乙型肝炎表面抗原(HBsAg)阳性携带者孕妇应用乙肝免疫球蛋白(HBIG)阻断乙肝病毒(HBV)母婴传播的效果.方法:将HBsAg阳性携带者孕妇所生新生儿分为HBIG组和对照组;HBIG组孕妇28、32、36周各注射HBIG 200 IU,对照组仅常规产检及监护;对新生儿出生时静脉血作乙肝两对半和HBV-DNA检测.结果:HBIG组新生儿的宫内感染率和HBV-DNA阳性率无明显降低,抗-HBs检出率无明显提高.结论:采用的HBIG接种时间和剂量尚未能完全有效阻断HBV的母婴传播.
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