乳腺癌患者治疗期间甲状腺功能的变化研究
Journal of Chongqing Medical University(2014)
Abstract
目的:探讨乳腺癌患者首次确诊时甲状腺功能(甲功)状况及化疗期间的甲功变化.方法:检测并比较112例原发性乳腺癌首诊患者与235例同期良性乳腺疾病患者首次入院时的甲功、93例乳腺癌患者化疗前与化疗期间的甲功及120例乳腺癌患者相邻两疗程化疗前的甲功变化.结果:乳腺癌首诊患者甲功低下发生率为21.4%,而乳腺良性疾病患者甲功低下发生率仅为7.2%,首次入院时乳腺癌首诊患者游离三碘甲状腺原氨酸(free triiodothyronine,FT3)水平低于良性乳腺疾病患者(t=-2.036,P=0.042),化疗期间乳腺癌患者甲功较化疗前降低[三碘甲状腺原氨酸(triiodothyronine,T3):t=13.427,P<0.001;四碘甲状腺原氨酸(tetraiodothyronine,T4):t=3.732,P<0.001;FT3:Z=-10.264,P<0.001;促甲状腺激素(thyroid stimulating hormone,TSH):t=8.201,P<0.001],相邻两疗程化疗前甲功无显著性变化(T3:t=0.170,P=0.865; T4:t=1.458,P=0.147; FT3:t=0.180,P=0.858; FT4:t=-0.973,P=0.333; TSH:t=-0.877,P=0.383).结论:乳腺癌患者首次确诊时多伴随低甲状腺功能状态,化疗期间甲功明显降低而在下一疗程化疗前甲功又明显恢复和改善.
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