类风湿关节炎血清学标志物联合检测的临床诊断价值
Journal of Shanxi Medical College for Continuing Education(2019)
Abstract
目的:探讨抗环瓜氨酸肽抗体(抗-CCP)、类风湿因子(RF)、RFIgA、RFIgG、RFIgM联合检测在类风湿关节炎(RA)的诊断价值.方法:分别检测149例RA患者,90例非RA患者及40例健康体检合格者,血清中类风湿因子(RF)采用速率散射比浊法检测;抗-CCP抗体、RFIgA、RFIgG、RFIgM采用酶联免疫吸附试验检测,计算其敏感性和特异性.结果:RA组RF、抗-CCP、RFI-sA、RFIsG、RFIgM的阳性率高于非RA组和对照组,差异有统计学意义(P<0.05).RA组抗体单项检测灵敏度最高为RF(92.62%),特异度最高为抗-CCP(91.11%).RA组联合检测灵敏度最高为抗-CCP+ RFgM (54.36%),特异度最高为抗-CCP+RFIgA+ RFgG+ RFgM(100.0%).联合检测抗-CCP抗体、RF-IgA、RF-IgG、RF-IgM,特异性最高为100%.结论:联合检测抗-CCP、RF及RF分型提高了临床对RA的诊断,降低了RA的漏诊率.
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