舌癌VEGF-C表达与颈淋巴结转移的关系及其临床意义
MEDICAL JOURNAL WUHAN UNIVERSITY(2005)
Abstract
目的:研究淋巴管生长因子(VEGF-C)表达与舌癌颈淋巴结转移的关系及其临床意义.方法:收集一期行颈淋巴清扫术的舌癌病例74例,行原发灶的VEGF-C免疫组化染色及颈淋巴结的细胞角蛋白(Cytokeratin,CK)AE1/AE3免疫组化染色,观察原发灶的VEGF-C表达情况及颈淋巴结转移情况.结果:74例患者中,VEGF-C高表达39例(52.7%),VEGF-C低表达35例(47.3%),有颈淋巴结转移者38例(51.4%).Fisher's 精确概率检验表明T1、T2期舌癌VEGF-C表达和颈淋巴结转移密切相关.单因素Logistic回归表明T1、T2期舌癌淋巴结转移与VEGF-C表达、T分期及N分期相关,而多因素Logistic回归表明T1、T2期舌癌淋巴结转移仅与VEGF-C表达相关(P<0.01).结论:VEGF-C表达对评估早期舌癌颈淋巴结转移有重要意义.
MoreKey words
Metastasis,Squamous-Cell Carcinoma
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