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Nanog、Snail在宫颈上皮内瘤变及宫颈癌中的表达及临床意义

Min Chen,Xinqiang Ji

Journal of Heze Medical College（2018）

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Abstract
目的 探讨宫颈癌中Nanog和Snail的表达及临床意义.方法 应用免疫组织化学SP法检测60例宫颈癌、20例宫颈上皮内瘤变和20例正常宫颈上皮组织中Nanog和Snail的表达情况.结果Nanog和Snail在宫颈上皮内瘤变和宫颈癌组织中的阳性表达增强,其中Nanog和Snail在宫颈癌中的表达显著增强.Nanog和Snail的表达呈正相关(r=0.457;P＜0.01).患者年龄、组织学分型、分化程度对Nanog和Snail阳性表达率无影响,但Nanog和Snail的表达与临床分期有关(P＜0.05).结论 Nanog和Snail在宫颈癌组织中高表达,Nanog和Snail有可能成为宫颈癌的生物学标志.
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