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GP73在肝细胞癌和胆管细胞癌中的表达

Fan ZOU,Xiao-hua JIE,Ying-hui CAO,Hua-qun FU,Rong-sheng WANG,Kai-yang WANG,Yu-hui CHANG

Acta Academiae Medicinae Jiangxi（2017）

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Abstract
目的 探讨血清高尔基体糖蛋白73(Golgi protein-73;GP73)对肝细胞癌及胆管细胞癌的诊断价值;方法采用双抗体夹心酶联免疫(ELISA)定量测定方法,检测60例肝细胞癌患者(Hepatocellular carcinoma,HCC)、50例胆管细胞癌患者(intrahepatic cholangiocarcinoma,ICC)以及30例健康献血者血清标本中高尔基体糖蛋白(Golgig-lycoprotein,GP37)的浓度.结果血清GP37在HCC组的表达明显高于ICC组以及健康组(P<0.05);GP37在诊断HCC的敏感度和准确度均要优于AFP(P<0.05),二者特异度的差异无统计学意义;GP37在诊断HCC的敏感度、特异度以及准确度均高于诊断ICC.结论GP37有可能成为诊断和鉴别诊断HCC和ICC新的临床肿瘤标记物.
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