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BAP1及其对透明细胞肾细胞癌的抑制作用

Ying Wu,Xueying Li,Youfu Pan

journal of zunyi medical university（2019）

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Abstract
肾癌在泌尿系统肿瘤中位居第三,其中约有80％的肾癌是透明细胞肾细胞癌(clear cell renal cell carcinoma,ccRCC).BAP1(BRCA1-associated protein 1)是一个重要的肿瘤抑制因子,通过去泛素化作用发挥多方面的功能,如参与转录调控、表观遗传调控、DNA损伤修复等.最近,研究发现体细胞BAP1突变可能促成ccRCC细胞中程序性细胞死亡配体1(programmed cell death-Ligand 1,PD-L1)的表达.本文综述了BAP1的结构功能及BAP1突变在ccRCC发生发展中的作用的相关进展,以期深入了解ccRCC的发生发展机制.
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