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CD44v6与ER的关系及其对乳腺癌预后的意义

郭贵龙,李卓英,杨正钦

JOURNAL OF CHANGZHI MEDICAL COLLEGE（2001）

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Abstract
目的:探讨CD44v6与ER的相互关系及其对乳腺癌预后的意义.方法:应用免疫组化法对66例乳腺癌标本进行检测,取12例乳房囊性病作对照.结果:CD44v6与乳腺癌TNM分期、肿瘤大小及腋窝淋巴结转移状况有明显的相关性;5年乳癌死亡组与生存组CD44v6表达比较差异有显著性意义(P＜0.05);CD44v6高表达者ER低表达,CD44v6低表达者ER则高表达.结论:CD44v6的表达与乳腺癌的进展、侵袭、转移能力的增强有关,与ER表达呈负相关趋势,可作为乳腺癌临床预测肿瘤侵润转移和估计预后的重要指标.
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