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HO-1对SH-SY5Y细胞中α-突触核蛋白和PLK2表达影响

Ranran WANG,Ning SONG,Hong JIANG,Junxia XIE

Acta Aacademiae Medicinae Qingdao Universitatis（2016）

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Abstract
目的 探讨血红素加氧酶-1(HO-1)对SH-SY5Y细胞中α-突触核蛋白与Polo样激酶2(PLK2)水平的影响.方法 采用Western blot方法,检测转染携带HO-1基因片段质粒48 h后的SH-SY5Y细胞α-突触核蛋白的表达.给予不同浓度的HO-1激动剂钴原卟啉(CoPPIX) 48 h后,检测SH-SY5Y细胞PLK2的表达.结果 高表达HO-1可降低细胞内α-突触核蛋白水平(t=2.672,P＜0.05),10和25 μmol/L的CoPPIX通过激活HO-1使PLK2表达上调(F=30.75,q=7.64、10.78,P＜0.01).结论 HO-1可使SH-SY5Y细胞中α-突触核蛋白表达下调,此过程可能与调控PLK2水平有关.
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