二烯丙基二硫与替莫唑胺联合应用对神经胶质瘤细胞U 251增殖凋亡的影响
Journal of Binzhou Medical University(2014)
Abstract
目的:探讨二烯丙基二硫(DADS)与替莫唑胺(TMZ)单独和联合应用诱导人神经胶质瘤细胞U251增殖凋亡的变化。方法分别使用DADS、TMZ单独用药和联合用药处理神经胶质瘤细胞株U251,采用四甲基偶氮唑盐(MTT)比色法检测细胞增殖情况,流式细胞术检测细胞凋亡情况。结果 DADS和TMZ联合应用与单独用药相比,可诱导U251细胞凋亡数量明显增多。结论 DADS可促进TMZ诱导U251细胞发生凋亡,可能是通过增加ROS产量发挥作用。
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