培美曲塞+顺铂和吉西他滨+顺铂治疗晚期肺腺癌的临床疗效

Dan-xia LIN,Chen CHEN,Yu-xian YANG,De ZENG,Xiao WU,Hui LIN,Cai-wen DU

Journal of Shantou University Medical College（2015）

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Abstract

目的:探讨培美曲塞或吉西他滨+顺铂治疗晚期肺腺癌的疗效和毒副作用.方法:64例晚期肺腺癌患者分为培美曲塞+顺铂(28例.培美曲塞500 mg/m2,第1d,顺铂25 mg/m2,第1～3 d)和吉西他滨+顺铂(36例.吉西他滨1 000 mg/m2,第1d及第8d,顺铂25 mg/m2,第1～3 d)组,治疗周期21 d.结果:培美曲塞、吉西他滨+顺铂组总有效率分别为32.1％和27.8％,中位无疾病进展时间6.7和6.3个月,中位生存期16.0和13.8个月.培美曲塞+顺铂组WBC减少、血小板降低明显低于吉西他滨+顺铂组(P＜0.05).结论:培美曲塞+顺铂可作为初治晚期肺腺癌安全有效的药物.

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