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丙种球蛋白对重症 EV71型手足口病患儿血清 IL-6,IL-10水平的影响

Acta Academiae Medicinae Weifang(2015)

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Abstract
目的:研究丙种球蛋白对肠道病毒71型(EV71)型重症手足口病(HFMD)外周血IL-6,IL-10的影响。方法将61例EV71感染的手足口病患儿根据病情分为普通组、重症组两组,同时以10例健康儿童作为对照组,采用双抗体夹心法酶联免疫吸附试验( ELISA)测定各组儿童治疗前后血清IL-6,IL-10的含量,并进行统计学分析。结果治疗前重症组血清IL-6,IL-10含量均高于普通组和对照组(P<0.01),静脉滴注免疫球蛋白(IVIG)治疗后重症组血清IL-6,IL-10明显降低(P<0.01)。结论重症早期应用丙种球蛋白可明显降低重症手足口病IL-6,IL-10水平,改善预后。
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Key words
Immunoglobulin,Severe hand-foot-mouth disease,Enterovirus 71,IL-6,IL-10
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