小剂量PGE1治疗重症心力衰竭的疗效观察
APPLIED JOURNAL OF GENERAL PRACTICE（2005）
Abstract
目的观察前列地尔(注射用前列腺素E1,PGE1)治疗重症心力衰竭的疗效.方法按NYHA心功能分级为Ⅲ～Ⅳ级、超声心动图左室射血分数＜35%的53例,在常规抗心衰治疗基础上,随机分为PGE1组27例和常规治疗组26例.PGE1组在常规治疗的基础上加用PGE1注射液80μg深静脉滴注,2次/d,10d为1疗程.两组均于治疗两周后复查超声心动图.结果治疗两周后,按NYHA分级,PGE1组较常规治疗组临床疗效更为显著;比较治疗前后超声心动图心功能指标左室舒张末内径、左室收缩末内径、左室射血分数,两组治疗后均有明显改善,而PGE1组患者改善更为明显;无明显副作用.结论在常规治疗基础上加用前列地尔深静脉滴注,重症心力衰竭患者的临床症状及心功能均有明显的改善,短期疗效显著,副作用小.
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Key words
low dose pge_1,severe heart failure,heart failure,clinical effects
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