转化生长因子-β调控内皮间充质转化的研究进展
Shanxi Medical Journal(2017)
Abstract
内皮间充质转化(endothelial-mesenchymal transition,EndMT)常被认为在胚胎期机体的正常发育及成年后机体对损伤的修复过程中发挥着重要的作用.近来发现,在某些病理条件下,转化生长因子(TGF)-β等炎性细胞因子分泌增多,一系列信号转导通路被激活,机体针对损伤修复的EndMT过程过度活化,进而导致组织及器官的纤维化、肿瘤的进展及远处转移等过程.
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