培哚普利对急性心肌梗死患者可溶性细胞黏附分子-1和细胞凋亡抑制因子的影响
Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi(2005)
Abstract
目的观察培哚普利急性心肌梗死患者(AMI)循环血可溶性细胞黏附分子-1(sICAM-1)和细胞凋亡因子(Fas/Apo-1)水平的影响。方法用酶联免疫方法检测66例AMI患者治疗前后中及34例健康人血中sICAM-1和Fas/Apo-1水平。结果AMI患者sICAM-1和Fas/Apo-1水平分别为(589.62±147.59)μg/Lvs(0.26±0.07)μg/L,显著高于健康对照组(175.34±30.06)μg/Lvs(0.13±0.03)μg/L,且随梗死范围扩大而升高,各组之间比较有显著意义,培哚普利组与治疗组对照组治疗前后血中sICAM-1和Fas/Apo-1浓度水平差异有显著意义,培哚普利组较治疗对照组治疗前后血中sICAM-1和Fas/Apo-1明显下降。结论外周血中sICAM-1和Fas/Apo-1水平可反映心肌梗死程度;培哚普利可明显下降低AMI患者血中sICAM-1和Fas/Apo-1的水平,从而缩小梗死范围改善心肌重构。
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