心力衰竭患者血清 NT-ProBNP 水平变化及意义
Shandong Medical Journal(2015)
Abstract
目的:观察心力衰竭(简称心衰)患者血清脑钠肽前体蛋白( NT-proBNP )水平变化,并探讨其意义。方法选取心衰患者150例(观察组)和健康体检者50例(对照组),采用双抗体夹心法检测两组血清NT-proBNP,彩色超声仪检测左心室射血分数(LVEF)。结果观察组血清NT-proBNP高于对照组,LVEF低于对照组,P均<0.01。观察组中,NYHA分级Ⅰ、Ⅱ、Ⅲ、Ⅳ级患者血清NT-proBNP依次升高(P均<0.01),且均高于对照组(P均<0.01)。血清NT-proBNP与心衰分级呈正相关(r=0.81,P<0.01),与LVEF呈负相关(r=-0.79,P<0.01)。结论随着病情加重,心衰患者血清NT-proBNP水平升高越明显;血清NT-proBNP水平检测,有助于心衰的早期诊断及心功能评估。
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