Prophylaxis of FANFT induced bladder tumours in rats by intravesical DNCB instillation.

Immunotherapy to prevent the appearance of superficial bladder tumours was studied in the (N(4-(5-Nitro-2-Furyl)-2-Thiazolyl Formamide) (FANFT) rat model. Intravesical 2, 4-dinitro-1-chlorobenzene (DNCB) was instilled beginning at six weeks after feeding the animals FANFT and given at montly intervals. Results showed no difference between control versus treated groups in tumour growth or lymphocytic infiltration near tumours. A significant incidence of calculi formation was noted in the DNCB group.