自噬和凋亡在肌少症中的研究进展

Ge GONG,Xiang YANG,Jian YIN,Xinghu ZHANG,Yuan ZHANG,Wenhui WAN

Acta Academiae Medicinae Sinicae（2018）

Cited 1|Views6

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Abstract

肌少症是与年龄相关的骨骼肌质量和功能进行性和全身性的损失,其原因为运动、营养、遗传因素、内分泌因素、炎症等,病理生理机制包括线粒体功能障碍、凋亡的过度激活、自噬的调节异常、卫星细胞功能的下降,活性氧产生增加等,本文总结了自噬及凋亡与肌少症的关系,并对调节自噬及减少凋亡在肌少症中的应用前景进行了展望.

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