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盐酸戊乙奎醚对脑胶质瘤术后患者肺部并发症的影响

Chinese Journal of Postgraduates of Medicine(2014)

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Abstract
目的 探讨术前肌肉注射盐酸戊乙奎醚对预防脑胶质瘤术后患者肺部并发症发生的影响.方法 择期行脑胶质瘤患者70例,年龄30 ~ 69岁,体质量50~80 kg,ASA分级Ⅱ或Ⅲ级,采用随机数字表法,将其分为两组(每组35例):对照组(C组),盐酸戊乙奎醚组(W组).两组麻醉诱导以及麻醉维持方法相同.W组于全身麻醉诱导前30 min肌肉注射盐酸戊乙奎醚20μg/kg(2 ml),C组以等容量0.9%氯化钠替代.于术后72 h内记录患者肺部并发症发生情况.结果 C组和W组肺部并发症发生率分别为28.6%(10/35)和11.4%(4/35).与C组比较,W组肺部并发症发生率降低(P<0.05).结论 术前肌肉注射盐酸戊乙奎醚20μg/kg可预防脑胶质瘤术后患者肺部并发症的发生.
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Key words
brain glioma resection,penehyclidine hydrochloride,postoperative pulmonary complications
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