反应溶媒对舒巴坦钠晶态的影响
JOURNAL OF HUAIHAI MEDICINE（2005）
Abstract
目的研究不同溶媒对舒巴坦钠晶态的影响.方法青霉烷砜酸在不同有机溶媒中与碱成盐后析出结晶,其产品用偏光显微镜观察.结果其产品的晶态存在显著差别.结论青霉烷砜酸在适当有机溶媒中成盐并化学结晶,其产品晶态能满足多种β-内酰胺类无菌原料的配伍需求,改善注射剂无菌分装工艺中粉体的流动性及混粉均一性等工艺特性[1].
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