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酸性鞘磷脂酶与帕金森病

Ying Wu,Yusen Chen,Zhuangsheng Wei

New Medicine（2020）

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Abstract
酸性鞘磷脂酶(ASMase)不仅介导溶酶体代谢,参与膜结构的调节和信号转导,而且对鞘磷脂转化为神经酰胺起关键作用.ASMase由鞘磷脂磷酸二酯酶1(SMPD1)基因编码.最近有研究显示SMPD1及ASMase与神经退行性疾病如帕金森病的发病和进展相关.该文就SMPD1及ASMase与帕金森病的相关研究进行介绍,以供同行们参考.
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