吉非替尼片溶出介质的筛选
Guide of China Medicine(2017)
Abstract
目的 筛选吉非替尼片pH 6.8溶出试验区分力曲线.方法 采用高效液相色谱外标法测定吉非替尼片的溶解性并测定pH 6.8的1%、2%、3%、4%、5%、6% 浓度吐温80介质的溶出曲线.结果 吉非替尼在5% 吐温80介质中溶解度为0.70 mg/mL且45 min溶出达到85%以上.结论 吉非替尼片采用5% 吐温pH 6.8介质具有区分能力.
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