血浆uPA、uPAR与鼻咽癌临床分期的相关性研究
Guide of China Medicine(2014)
Abstract
目的:探讨尿激酶型纤溶酶原激活物(uPA)及其受体(uPAR)的血浆浓度与鼻咽癌临床分期和恶性程度的相关性。方法收集86例鼻咽癌患者血液标本,35例健康人血液标本作对照。用酶联免疫吸附法(ELISA法)分别检测uPA和uPAR的血浆浓度。结果与健康对照患者比较,鼻咽癌组血浆uPA浓度明显升高(P<0.05),且鼻咽癌组血浆uPA、uPAR在鼻咽癌各期之间均有显著性差异(P<0.05)。结论鼻咽癌的临床分期和恶性程度与血浆uPA浓度高度正相关,可作为鼻咽癌诊断和预后估计的指标及治疗的新靶点。
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