胃癌患者血清ORP150水平及其临床意义
Journal of Medical Research(2016)
Abstract
目的 探讨胃癌患者血清中氧调节蛋白150(oxygen-regulated protein 150,ORP150)的水平及其临床意义.方法 采用ELISA法检测60例胃癌患者、30例体检正常者血清中的ORP150含量,分析其与胃癌临床病理特征的关系.结果 胃癌患者血清ORP150的水平7.06±0.56ng/ml明显高于正常对照组2.11±0.28ng/ml(P<0.05);胃癌患者中Ⅲ、Ⅳ期血清ORP150水平明显高于Ⅰ、Ⅱ期(P<0.05);中低分化组血清ORP150水平明显高于高分化组(P<0.05);血清ORP150水平随着浸润深度的增加而增高(P<0.01);淋巴结转移组血清ORP150水平明显高于无淋巴结转移组(P<0.01);而血清ORP150水平与年龄、性别、肿瘤直径无关.结论 胃癌患者血清ORP150水平增高,与肿瘤TNM分期、分化程度、浸润深度、淋巴结转移有关.
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