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缺血预处理对减轻肢体缺血再灌注性肺损伤的临床观察

郑燕国,吴熙文,朱云森,郑敏巧,许建军

China Higher Medical Education（2016）

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Abstract
目的:观察缺血预处理对减轻肢体缺血再灌注性肺损伤的效果.方法:选择单侧下肢手术60例,采用随机数字表法,将患者分为C组和IPC组,每组各30例.结果:与T1比较,C组在T4时RI升高,在T3、T4时OI降低(P＜0.05).IPC组在T1-T5各时点RI、OI比较差异无统计学意义(P＞0.05).与C组比较,IPC组在T3-T5时血浆血浆IL-6、IL-8浓度明显降低(P＜0.05).结论:缺血预处理减轻了机体炎症反应和肺部毛细血管和肺泡的损伤,从而对肢体缺血再灌注性肺损伤起到预防作用.
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