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基于TMB对肺癌免疫治疗病例分析

Juan LI,Chongyi LI,Yanli XIONG,Xian-feng LU,Nan DAI,Shiheng ZHANG,Wei LUO,Mengxia LI

Journal of Modern Medicine & Health（2018）

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Abstract
免疫检查点抑制剂(ICIs)为晚期肺癌患者带来了长期生存的希望,但目前各项临床研究和临床实践均证实肺癌患者对ICIs治疗的有效率较低(10％～30％).如何发现新的生物标记物筛选ICIs治疗的有效人群是目前研究的热点.本课题组在前期临床工作中使用临床全外显子测序(WES)得到的肿瘤突变负荷(TMB)的结果来指导肿瘤患者的ICIs治疗.
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