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miRNA152-3p在前列腺癌的变化及其意义

Heilongjiang Medicine And Pharmacy(2019)

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Abstract
目的:观察miRNA152-3p在前列腺癌患者血清中的水平变化,并探讨其意义.方法:选择前列腺癌患者30例(PCa组)、前列腺增生患者30例(BPH组).采取各组血清,采用实时荧光定量免疫技术检测血清水平,分析水平与前列腺癌临床病理特征的关系.结果:miRna-152-3p在血清中高表达与患者年龄无统计学意义(P>0.05),与临床分级、Gleason评分、有无骨转移、血清tPSA水平(P<0.01)具有统计学意义.结论:miRna-152-3p与前列腺癌组织的浸润、转移及预后有关,可作为疾病诊断、预后因子及相关靶向药物抑制转移因子.
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