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小剂量甲氨蝶呤引起中毒性表皮坏死松解型药疹一例

魏威胜,张娇

Youjiang Medical Journal（2019）

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Abstract
中毒性表皮坏死松解症( TEN)是一种严重的重 症药疹,临床少见,近年国内外的文献报道中,因较小剂量的甲氨蝶呤( MTX)导致的TEN更为罕见. 本例患者因系统性红斑狼疮( SLE)使用小剂量MTX后,迅速出现中毒性表皮坏死松解型药疹,发病急且病情重,皮损累及全身皮肤约33％,应用糖皮质激素和丙种球蛋白冲击治疗后,预后良好,现报告如下.
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