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miR-21与肺部疾病关系研究进展

刘坤, 戴爱国,蒋永亮

Modern Medicine Journal of China（2014）

Cited 0|Views7
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Abstract
microRNAs (miRNA)是近年来新发现的一类内源性、非编码单股小分子RNA,长度约为19～25个核苷酸,广泛存在于真核生物中,通过转录后修饰参与生理与病理过程.miRNA在细胞核转录成原始产物(pri-miRNA),经过Drosha消化之后生成pre-miRNA然后转运至细胞质经Dicer酶消化生成miRNA,通过与靶mRNA 3'UTR完全或不完全的互补结合,导致靶mRNA降解或翻译抑制,从而调控靶基因的表达,影响细胞增殖、分化和凋亡.
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