新型电荷反转型阳离子载体与BCSG1-siRNA纳米粒靶向治疗Luminal B型乳腺癌

Henan Medical Research（2020）

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Abstract

2020年美国癌症协会发布肿瘤统计报告,女性中最常见的癌症是乳腺癌、肺癌和结直肠癌,占新发病例数过半,其中乳腺癌独占新发病例数的30％[1].Luminal B型乳腺癌是乳腺癌分子分型中最常见的亚型,占47.7％～52.8％[2-3].Luminal B型乳腺癌发病率高,激素受体低表达,增殖指数Ki67高表达,与Luminal A型乳腺癌比较,内分泌治疗效果差、往往预后不良[4].

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