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宫颈癌的病因及发病机制研究进展

Hong-juan SHI,Ting-ting SHAO,Qun-feng LI,Mei-jiao ZHU,Hua ZHAO,Rui-fang LIU, Xing LIU,Shui-hong YAO

World Latest Medicine Information（2020）

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Abstract
宫颈癌在全球范围内是导致女性死亡的常见原因,为常见的妇科恶性肿瘤,晚期、复发及转移使宫颈癌的治疗面临挑战,然而对其发病机制尚未完全明确.本文将简要综述宫颈癌的最新研究进展,包括自噬相关PI3K-Akt-mTOR信号通路、自噬相关基因Ambra1、VEGF信号通路、p53信号通路、Klotho信号通路、微小RNAs、免疫检查点等,旨在为妇科肿瘤的治疗提供理论依据.
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