P16/ki67双染在宫颈病变中应用的研究进展
Journal of Clinical Medical Literature (ElectronicEdition)(2020)
Abstract
从早期宫颈病变到宫颈癌的缓慢发展给癌前病变的识别和干预提供了机会,所以宫颈癌防治的关键是预防性的筛查和识别早期病变.大量文献报道了宫颈在HPV感染的细胞转化过程中,发生了P16和Ki67的失调,这些分子可用于区分宫颈非肿瘤性病变与宫颈癌前病变,并且可以评估个体癌前病变级别的级别、进展和消退.
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