HPLC-MS/MS法同时测定口服液保健食品中非法添加的降压和壮阳抗疲劳类药物

Xi ZENG,Ping QI,Ning WANG,Zihao LIN,Zhenjie QIAN,Qingqiong ZHOU,Weiyi CAI,Mingjun PFNG

AEM RODUCTS ROCESSING（2020）

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Abstract

对流动相、洗脱梯度、质谱条件和样品前处理方法进行优化,采用高效液相色谱-串联质谱法(HPLC-MS/MS)对22种违禁药物分离和定量测定.液体样品经提取,过C18色谱柱,采用甲酸-乙酸铵水溶液和乙腈为流动相,梯度洗脱.电喷雾离子(ESI+)源、正离子模式下采用多反应监测(MRM)模式检测.结果表明,利血平等22种非法添加的药物在1.0～50.0 ng/mL内线性均良好,相关系数(r)均在0.99以上,3个水平加标回收率为77.15％～116.73％,相对标准偏差(RSD)亦未超过11％(n=6).此方法简单、快速、可靠,能满足日常检验要求.

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