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羧甲基葡聚糖对H5亚型禽流感灭活疫苗免疫效果的影响

李志,孙英峰,付永利,于海霞,张立新,唐佩娟,张丹,李泽青,何佳

China Poultry（2016）

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Abstract
研究旨在探讨羧甲基葡聚糖对H5亚型禽流感灭活疫苗免疫效价影响.选取7日龄健康SPF鸡80只,随机分为4组,每组20只.试验组以羧甲基葡聚糖作为疫苗伴侣,终浓度为50 g/100 mL、5g/100 mL、0.5 g/100 mL,对照组为常规疫苗.试验周期为35 d.采用ELISA测定抗体阳性率及HI检测血凝抑制抗体效价.结果表明:5g/100 mL羧甲基葡聚糖可以提高H5亚型禽流感疫苗对鸡的免疫效力,且持续到42日龄,可在肉鸡饲养全过程有效预防禽流感疾病发生.
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