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正交试验法优选参贝补肺丸的制备工艺

Guangbin LIU,Yan WANG, Yuye ZHANG,Lin MAO,Heping MAO,Fangning JIANG,Liping ZHAO,Yuming DONG

Journal of Traditional Chinese Veterinary Medicine（2020）

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Abstract
通过正交试验法优选确定参贝补肺丸的制备工艺路线.在预试验的基础上,对参贝补肺丸的泛丸、成型工艺条件进行优选,对丸粒的光泽、圆整度进行观察对比,对溶散时限、水分、丸重差异、微生物、含量进行测定.结果 泛丸工艺为生药细粉粉碎至100目,纯化水质量:药粉质量为0.5∶1,丸粒大小约6.0 mm,60℃干燥10 h,成型丸剂符合规定.提示参贝补肺丸制备工艺切实可行,各项检测指标符合参贝补肺丸质量标准(草案)规定,适合批量化生产.
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