连翘联合抗菌药物对多重耐药大肠杆菌B3的抗菌试验
Shanghai Journal of Animal Husbandry and Veterinary Medicine(2018)
Abstract
目的:测定连翘水煎剂及其与抗菌药物联合对多重耐药大肠杆菌(Escherichia coli,E.coli)B3菌株的抑菌效果.方法:采用牛津杯法测定连翘对B3菌的抑菌作用,利用微量肉汤稀释法测定连翘、四环素和磺胺间甲氧嘧啶钠对B3菌的最小抑菌浓度(minimum inhibitory concentra-tion,MIC);通过棋盘稀释法来测定连翘和上述抗菌药物的联合抑菌效果.结果:连翘能抑制多重耐药大肠杆菌B3菌株的生长繁殖,呈现抗菌作用;试验药物对B3菌株的最小抑菌浓度分别为连翘125.0 mg/mL、四环素12.8 mg/mL、磺胺间甲氧嘧啶钠50.0 mg/mL;部分抑菌浓度(fractional inhibitory concentration,FIC)指数结果显示连翘与四环素联合呈相加作用,连翘与磺胺间甲氧嘧啶钠联合呈无关作用.本试验为兽医临床解决细菌耐药问题提供了用药新思路,同时为开发中草药制剂提供依据.
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